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High risk is a designation given to certain crops and organisms, and their derivatives, that triggers a deeper evaluation under the Product Verification Program. Because of the abundance of GMO acreage, high-risk inputs are likely to be derived from GMOs unless intentionally sourced Non-GMO. Participants using high-risk inputs must take extra care to validate that Non-GMO versions are being sourced for their products. This guide clarifies the meaning of high-risk crops and organisms, and provides illustrative examples.